ABSTRACT
OBJECTIVES: The aim was to compare the incidence of Staphylococcus aureus bacteremia in COVID-19 and non-COVID-19 adult patients during the pandemic period versus the previous two years. Also, we described the characteristics of both cohorts of patients in pandemic period to find differences. MATERIAL AND METHODS: Retrospective study in our tertiary-care centre reviewing S. aureus bacteremia episodes in COVID-19 and non-COVID-19 patients through clinical records and the Microbiology Department database. RESULTS: In 2018 and 2019, the incidence of S. aureus bacteremia episodes was 1.95 and 1.63 per 1000 admissions respectively. In the pandemic period, global incidence was 1.96 episodes per 1000 non-COVID-19 admissions and 10.59 episodes per 1000 COVID-19 admissions. A total of 241 bacteremia was registered during this pandemic period in 74 COVID-19 patients and in 167 non-COVID-19 patients. Methicillin resistance was detected in 32.4% and 13.8% of isolates from COVID-19 and non-COVID-19 patients respectively. In COVID-19 patients, mortality rates were significantly higher. CONCLUSIONS: We showed a significantly high rates of S. aureus bacteremia incidence in COVID-19 patients and higher methicillin resistance and 15-day mortality rates than in non-COVID-19 patients.
Subject(s)
Bacteremia , COVID-19 , Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections , Adult , Humans , Staphylococcus aureus , Retrospective Studies , COVID-19/epidemiology , SARS-CoV-2 , Staphylococcal Infections/microbiology , Bacteremia/epidemiology , Bacteremia/microbiologyABSTRACT
Infectious spondylodiscitis (ISD) is a rare infection of the spine. ISD caused by Acinetobacter baumannii and Citrobacter koseri is even rarer. Moreover, the association between ISD and malignancy is uncommon. In these case series, we report the remarkable case of a patient diagnosed with ISD associated with bone metastatic lesions of an unknown cancer and multiple myeloma accidentally discovered due to COVID-19 infection. We also reported two cases of ISD caused by rare organisms: the first case is a man with ISD caused by a multidrug resistant A. baumannii, and the second is a man with C. koseri bacteraemia complicated by paraspinal abscess and ISD. Resumen La espondilodiscitis infecciosa (EDI) es una infección rara de la columna vertebral, la enfermedad causada por Acinetobacter baumannii y Citrobacter koseri es aún más rara. Además, la asociación entre EDI y malignidad es un hecho poco común. En esta serie de casos presentamos el caso destacado de un paciente diagnosticado con EDI asociado con lesiones metastásicas óseas de un cáncer desconocido y mieloma múltiple de descubrimiento accidental con motivo de infección por COVID-19. También, reportamos dos casos de EDI causados por microorganismos inusuales: el primer caso es un hombre con EDI causada por Acinetobacter baumannii multirresistente, y el segundo es un hombre con bacteriemia por Citrobacter koseri complicada con absceso paraspinal y EDI.
ABSTRACT
INTRODUCTION: The reasons for the decrease in blood cultures were investigated and the rate and aetiology of bacteremia and contaminated blood cultures collected from COVID and non-COVID patients were assessed. METHODS: We performed a retrospective analysis in a tertiary hospital in Spain during the COVID period from 4th March 2020 to 21st June 2020. RESULTS: The number of blood cultures processed was 5313, representing 22.7% and 18.8% of decrease compared to the same months of 2019 and 2018, respectively (p=0.173). The rate of bacteremia was 1.2% higher among COVID-patients than among non-COVID patients (p<0.001). COVID patients had a higher proportion of nosocomial bacteremia (95.5%) than non-COVID patients (30.5%) (p<0.001). In COVID-positive patients, the contamination rate was 12.3% vs 5.7% in non-COVID patients (p<0.001). CONCLUSION: There was a decrease in the number of blood cultures collected during the COVID period compared to previous years. Bacteremia in COVID patients was mainly nosocomial and catheter-related.
Subject(s)
Bacteremia , COVID-19 , Cross Infection , Bacteremia/epidemiology , Bacteremia/etiology , COVID-19/epidemiology , Cross Infection/epidemiology , Humans , Pandemics , Retrospective Studies , Spain/epidemiology , Tertiary Care CentersABSTRACT
INTRODUCTION: The reasons for the decrease in blood cultures were investigated and the rate and aetiology of bacteremia and contaminated blood cultures collected from COVID and non-COVID patients were assessed. METHODS: We performed a retrospective analysis in a tertiary hospital in Spain during the COVID period from 4th March 2020 to 21st June 2020. RESULTS: The number of blood cultures processed was 5313, representing 22.7% and 18.8% of decrease compared to the same months of 2019 and 2018, respectively (p=0.173). The rate of bacteremia was 1.2% higher among COVID-patients than among non-COVID patients (p<0.001). COVID patients had a higher proportion of nosocomial bacteremia (95.5%) than non-COVID patients (30.5%) (p<0.001). In COVID-positive patients, the contamination rate was 12.3% vs 5.7% in non-COVID patients (p<0.001). CONCLUSION: There was a decrease in the number of blood cultures collected during the COVID period compared to previous years. Bacteremia in COVID patients was mainly nosocomial and catheter-related.